Evidence-Based Longevity — What Actually Works
Your Guide to Living Longer & Better
Cutting through the noise in longevity science — so you know what actually works.
Why We Exist
Longevity science drops new studies daily. Most contradict each other. Supplements, protocols, biohacks — the noise is deafening, and the stakes are your health.
Information is free. Trusted curation is not.
We don't exist to add more studies to your pile. We exist to tell you which ones are worth acting on — and why. We read the papers, check the methodology, track the consensus, and hand you the signal.
Every recommendation we make comes with a simple test: would we give this to our own family?
Our Evidence Tiers
Every finding is graded so you know exactly how solid the ground is:
| Tier | Label | What It Means |
|---|---|---|
| 🥇 | Gold | Meta-analysis, systematic review, or large RCT with replication |
| 🥈 | Silver | Single RCT, strong observational study, or consistent preclinical + early human data |
| 🥉 | Bronze | Preclinical (animal/cell), mechanistic plausibility, small pilot study |
| ⚠️ | Emerging | Anecdotal, N-of-1, very early signal — interesting but unproven |
Explore by Category
Supplements & Compounds
What to take, what to skip — with evidence tiers. NMN, NAD+, rapamycin, metformin, senolytics, spermidine, and more.
🧪Peptides & Bioregulators
BPC-157, Epitalon, GHK-Cu and the emerging peptide landscape — what's real and what's hype.
💊Brand New Drugs
Just-approved and pipeline drugs that target aging biology directly.
⚡Breaking Now
New studies, trial results, and approvals from the last 30 days.
🔭On the Horizon
Preclinical, Phase I/II, early signals — what's coming next.
🧬The Fundamentals
How aging actually works — hallmarks, mechanisms, and core biology explained for normal humans.
🌿What's Working Naturally
No pills — diet, exercise, sleep, fasting, and the free stuff that moves the needle.
😴Sleep & Longevity
Why sleep is your body's repair shop, and how to actually get more of it.
🏗️Protocols & Biohacks
Real regimens, tracking, and data-driven self-experimentation.
📖History & Context
How we got here — key discoveries and the scientists who built the field.
🦠The Microbiome
Why your gut bugs control how you age — and what to do about it.
🗣️Community Voices
What's working for real people — case studies and N-of-1 experiments.
This Week in Longevity
August 17, 2026 — Curated highlights you should know about
- 🥇 Exercise delays ovarian aging — and we now know how. A Nature Aging study of 152,435 women found physically active women had later menopause and lower FSH, the hormone that climbs as ovaries age. PMID: 42601407
- 🥇 Which exercise best prevents falls? A network meta-analysis finally ranks them. Pooling dozens of trials in adults 60+, this analysis found different exercise types are best for different kinds of balance. PMID: 42600321
- 🥈 Senolytics reverse air-pollution damage to blood vessels. In mice exposed to PM2.5, drugs that clear "zombie cells" reversed the early artery damage and inflammation. PMID: 42593595
- 🥈 Broken polyamine metabolism is a new driver of age-related muscle loss. A 3D gene-activity map of aging muscle revealed the machinery for polyamines — including spermidine — breaks down with age. PMID: 42602328
- 🥈 Blue Zone living shows up in quality of life, not just lifespan. In 421 Loma Linda residents 75+, vegetarian diets and healthy lifestyle predicted better quality of life. PMID: 42601992
Also Noteworthy
- 🥈 Metformin at the convergence of aging and longevity — a new review maps how metformin's AMPK activation touches multiple hallmarks of aging, but the definitive TAME trial still hasn't reported. PMID: 42579881
- 🥈 Boosting autophagy reverses age-related mitochondrial damage in human neurons. PMID: 42604495
- 🥉 Four natural compounds, one goal — spermidine, fisetin, berberine, and urolithin A as complementary "functional foods" against aging hallmarks. PMID: 42588134
- 🥈 Aquatic exercise reduces fall risk in older adults. PMID: 42603704
- 🥈 Ketones as an early "on track?" signal for diabetes reversal. PMID: 42603220